Drug Info
- Brand Names: Xarelto, Rivasmart;
- Active Ingredient: Rivaroxaban;
- Manufacturer: Bayer.
Xarelto and its drug substance Rivaroxaban
Rivaroxaban is an active ingredient based on which Xarelto was developed. The drug belongs to direct Factor Xa inhibitors that are essential in the process of blood clotting. Xarelto tablets help lower the risk of thromboembolic complications and prevent the formation of thrombi by slowing down blood clotting.
Unlike parenteral anticoagulants, Xarelto has the following benefits:
- Oral administration;
- Simple dosage regimen;
- No need to constantly/regularly monitor a patient’s state;
- A lower risk of interaction with food and drugs.
Rivaroxaban starts working in about one to three hours. The peak effect is seen three to four hours after administration.
Indications
Areas of Xarelto uses:
- Therapy, prevention, or lowering of the risk of recurrence of blood clots in vessels of the lungs or/and legs;
- Prevention of blood clots in vessels after surgery, for example, of the hip or knee joint prosthesis installation.
The drug can be used off-label to lower the risk of severe cardiovascular events and thromboembolic complications under other conditions.
Treatment regimens and Xarelto dosage
It is important to mention that a doctor can prescribe Xarelto proper dosage and treatment regimen, depending on a patient's history or the nature of their disorder. Patients must follow a doctor’s recommendations and monitor their state under medical supervision.
The standard regimen of Xarelto in adults:
- A typical daily dose - Xarelto 10 mg or 20 mg daily;
- Dosing schedule - 1 or 2 times per day.
For oral anticoagulants to be effective, one needs to be careful to the details and adhere to certain rules.
The dosage regimen can vary greatly depending on the treatment stage, medical condition, and individual characteristics of your body.
Recommendations on the use
Many oral anticoagulants need to be taken regularly at a particular time of day. Self-discipline is required to maintain a stable level of Rivaroxaban in the body. Follow the following tips and recommendations to get the maximum effect from the treatment:
- It is essential to take the drug at the same time every day;
- Missing even one dose may increase the risk of blood clotting and thromboembolic events;
- Swallow the whole tablet with a glass of water;
- You can grind the pill and mix it with water or apple sauce if needed;
- The medicine can be taken regardless of the meal.
Failure to follow these recommendations will decrease the effect of the drug, thus lowering its benefits to your body.
Missed Dose
Before starting the treatment, ask your doctor what to do in case you miss a dosage. Recommendations may vary depending on the dosage regimen and a patient’s age.
Precautions
Xarelto 10 mg and 20 mg doses are not suitable for people with certain diseases. Sometimes, these doses can be used only with caution. Please inform your doctor if you have at least one of the following conditions before starting the treatment with Xarelto:
- Dysfunction of the internal organs, including the kidney;
- Pathologies that may cause bleeding;
- Dysfunction of blood coagulation;
- Uncontrolled high blood pressure;
- Pregnancy, plans for pregnancy, or breastfeeding;
- Surgery for heart valve replacement.
You should be cautious when using anticoagulants to avoid an increased risk of injury. Avoid situations that may result in cuts, bruises, or abrasions, and be careful when practicing sports.
Use of Xarelto during pregnancy
This drug should not be taken during pregnancy or breastfeeding unless your doctor advises otherwise. Immediately inform your doctor if you get pregnant during the treatment.
Possible Xarelto side effects
In clinical trials, Xarelto tablets and the active ingredient Rivaroxaban were proven to be safe anticoagulants. However, they can cause adverse reactions, including the following:
- Dry mouth;
- Weakness;
- Fatigue;
- Pain in the limbs;
- Muscle spasms;
- Abdominal pain.
Important! Medications that contain Rivaroxaban reduce the clotting of blood, which may result in more intensified hemorrhage even in case of minor injuries, including gum bleed, nosebleeds, gastrointestinal hemorrhage, etc.
Some patients may experience allergic reactions to oral anticoagulants. They may manifest as itching, skin rash, edema, shortness of breath, and other symptoms.
Xarelto: interaction with other drugs
Oral anticoagulants can interact with other drugs and lead to adverse reactions. Always inform your doctor that you take anticoagulants when starting another treatment.
The drugs and substances listed below may interact with Xarelto (Rivaroxaban):
- St. John's Wort;
- Ritonavir;
- Itraconazole;
- Ketoconazole;
- Warfarin;
- Platelet aggregation inhibitors;
- Nonsteroidal anti-inflammatory drugs.
Uncontrolled interactions may increase the risk of hemorrhage, cause side effects, or decrease the effectiveness of Xarelto. Always check whether new medications that you must take interact with anticoagulants you are already taking and follow your doctor’s recommendations.
Storage
Store Xarelto in a cool (from 15°C to 30°C) and dry place, away from sunlight. It is important to be sure you have enough tablets to continue the treatment course. Don’t leave the drug in the car during trips in hot weather; you’d better keep it in your bag. It is advised to store your medications in your hand luggage when traveling by plane.
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